Cervical Cancer Diagnosis Process

Cervical Cancer Diagnosis Process

Cervical Cancer Diagnosis Process

The diagnosis of cervical cancer typically involves several steps:

It’s important to consult with a healthcare professional for a proper diagnosis and to discuss treatment options if cervical cancer is suspected. Early detection and treatment can significantly improve outcomes.

  1. Screening:

  Pap Smear: A Pap smear, also known as a Pap test, is a routine screening where a healthcare provider collects cells from the cervix during a pelvic exam. These cells are then examined under a microscope to check for abnormalities, such as precancerous or cancerous cells.
      HPV Test: In addition to a Pap smear, an HPV test may be conducted. This test checks for the presence of high-risk strains of the human papillomavirus (HPV), which is a major risk factor for cervical cancer. HPV testing can be done alone or in combination with a Pap smear.

  1. Colposcopy:

      If the results of a Pap smear or HPV test indicate abnormalities, a colposcopy may be recommended. During this procedure, a colposcope (a magnifying instrument) is used to closely examine the cervix. A special solution may be applied to the cervix to make abnormal areas more visible.

  1. Biopsy:

  If the colposcopy reveals suspicious areas or abnormal tissue, a biopsy is performed. During a cervical biopsy, a small sample of tissue is removed from the cervix using various methods, such as punch biopsy or cone biopsy.

  The collected tissue sample is sent to a laboratory where it is examined by a pathologist under a microscope. This helps determine if cancerous cells are present and provides information about the type and stage of cervical cancer.

  1. Imaging:

      If cervical cancer is confirmed, imaging tests may be ordered to assess the extent of the cancer and whether it has spread. Common imaging methods include Magnetic Resonance Imaging (MRI), Computed Tomography (CT) scans, and Positron Emission Tomography (PET) scans.

  1. Staging:

      Once all necessary information is gathered, the healthcare team stages the cancer. Staging involves determining the size of the tumor, whether it has invaded nearby tissues, and whether it has spread to lymph nodes or distant organs. Staging helps guide treatment decisions and prognosis.

Remember, the specific diagnostic process may vary depending on individual circumstances and healthcare practices. It’s crucial to discuss your situation with a healthcare provider who can provide personalized guidance and answer any questions you may have about cervical cancer diagnosis. Early detection and timely treatment are key to better outcomes.

Today we shall discuss more about Pap smear.

Pap smear, also known as a Pap test or cervical cytology, is a routine screening test primarily used to detect abnormal cervical cells that may indicate the presence of cervical cancer or precancerous changes. Here’s a more detailed explanation of the Pap smear procedure:

  1. Preparation:

  You’ll typically schedule a Pap smear with your healthcare provider, usually during a pelvic exam.

  It’s often recommended to avoid sexual intercourse, the use of vaginal medications, and douching for at least 24 to 48 hours before the test, as these activities may interfere with the accuracy of the results

  1. Procedure:

  You’ll lie on an examination table with your feet placed in stirrups, similar to a pelvic exam.

      The healthcare provider will use a speculum to gently open the vaginal walls, allowing them to access the cervix.

  Using a small spatula or brush, they will collect a sample of cells from the cervix. This process may cause a brief sensation of pressure or discomfort but should not be painful.

  1. Sample Collection:

      The collected cells are typically placed in a vial with a liquid preservative or on a glass slide. The choice of collection method may vary depending on the healthcare provider’s preferences and laboratory practices.

  1. Laboratory Analysis:

  The collected cell sample is sent to a laboratory for analysis.

      In the lab, the cells are stained and examined under a microscope by a trained cytotechnologist or pathologist.

  The pathologist will look for any abnormal changes in the cervical cells, including precancerous or cancerous cells.

  1. Results:

      The results of the Pap smear are usually reported as one of the following:

  Normal: No abnormal cells were found.

      Abnormal: Changes in the cervical cells are detected. These changes can range from mild (low-grade) to severe (high-grade).

  Inadequate or Unsatisfactory: Sometimes, the sample collected may not be suitable for analysis due to insufficient cells or other factors, requiring a repeat Pap smear.

  1. Follow-Up:

      Depending on the results, further testing or follow-up may be recommended. For instance, if abnormal cells are found, a colposcopy or biopsy may be advised to investigate further.,

The age-related guidelines for Pap smears have evolved over the years based on the individual’s risk factors and prior screening results. Here are some general guidelines:

  1. Under 21 Years Old:

      Pap smears are generally not recommended for individuals under 21, regardless of sexual activity or HPV status. This is because cervical cancer is rare in this age group, and abnormal cells often resolve on their own.

  1. Ages 21-29:

      Starting at age 21, it’s recommended to have a Pap smear every three years. Co-testing with an HPV test is not typically necessary in this age group unless there are specific risk factors or abnormal results.

  1. Ages 30-65:

      Women aged 30 to 65 can choose one of the following options:

  Pap smear alone every three years.

  Co-testing with a Pap smear and an HPV test every five years (preferred).

      Co-testing provides a more comprehensive screening strategy and can detect HPV, which is the primary cause of cervical cancer.

  1. Over 65 Years Old:

  If a woman has had regular screenings with normal results and no high-risk HPV for several years, she may choose to stop cervical cancer screening after age 65.

  Women who have had a history of abnormal results or other risk factors may need continued screening.

  1. After Hysterectomy:

      If a woman has had a total hysterectomy (removal of the uterus and cervix) for non-cancerous reasons (such as fibroids or heavy bleeding) and has no history of cervical cancer or significant cervical pre-cancer, Pap smears are usually not necessary.

  1. After Vaccination:

      Continue to have screened for cervical cancer.


It’s important to note that these guidelines provide a general framework, and individual recommendations may vary based on personal health history, risk factors, and the advice of a healthcare provider. Regular discussions with your healthcare provider are essential to determine the most appropriate cervical cancer screening schedule for your specific situation.



Written by
Dr. Partha Sarathi Bhattacharyya,
MD,  Radiation Oncologist
Mahatma Gandhi Cancer Hospital and Research Institute, Visakhapatnam